September 26, 2023
All-Antibody

Antibodies In Frontotemporal Dementia Neurotransmission And Synaptic

Anti-GluA3 antibodies in frontotemporal dementia: results on glutamatergic neurotransmission and synaptic failure.

Regardless of the good effort of the scientific group within the discipline, the pathogenesis of frontotemporal dementia (FTD) stays elusive. Lately, a task for autoimmunity and altered glutamatergic neurotransmission in triggering illness onset has been put ahead. We reported the presence of autoantibodies recognizing the GluA3 subunit of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in about 25% of FTD circumstances.

 

On this examine, we evaluated the mechanisms concerned in anti-GluA3 autoimmunity, via molecular/neurochemical analyses carried out on sufferers’ mind specimens with frontotemporal lobar degeneration-tau neuropathology. We then corroborated these ends in vivo in FTD sufferers with transcranial magnetic stimulation and glutamate, D-serine, and L-serine dosages within the cerebrospinal fluid and serum.

All-Antibody
All-Antibody

We noticed that GluA3 autoantibodies have an effect on glutamatergic neurotransmission, lowering glutamate launch and altering GluA3-containing α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor ranges. These alterations have been accompanied by adjustments of scaffolding proteins concerned in receptor synaptic retention/internalization.

 

The above outcomes have been confirmed by transcranial magnetic stimulation, suggesting a big impairment of oblique measures of glutamatergic neurotransmission in FTD sufferers in contrast with controls, with additional add-on dangerous impact in these FTD sufferers with anti-GluA3 antibodies. Lastly, FTD sufferers confirmed a big enhance of glutamate, D-serine, and L-serine ranges within the cerebrospinal fluid.

 

Human anti TNF Alpha autoantibody ELISA kit

E01A2132-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Human anti TNF Alpha autoantibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Anti-human Topoisomerase II alpha (TOP2 alpha) IgG, aff pure

TOP2A11-A 100 ug
EUR 578.4

Canine Tumor Necrosis Factor alpha (TNF-a) ELISA Kit, 96 tests, Quantitative

10460 1 Kit
EUR 927.6

Bovine Tumor necrosis factor alpha (TNF-A) ELISA Kit, 96 tests, Quantitative

9810 1 Kit
EUR 927.6

Antibody for Human TNF alpha

SPC-1315D 0.1ml
EUR 376.8
Description: A polyclonal antibody for TNF alpha from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human TNFA.. The Antibody is tested and validated for IHC, ICC/IF, ELISA assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:500), ELISA (1:10000). This TNF alpha antibody is unconjugated.

Antibody for Human TNF alpha

SPC-1315D-A390 0.1ml
EUR 433.2
Description: A polyclonal antibody for TNF alpha from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human TNFA.. The Antibody is tested and validated for IHC, ICC/IF, ELISA assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:500), ELISA (1:10000). This TNF alpha antibody is conjugated to ATTO 390.

Antibody for Human TNF alpha

SPC-1315D-A488 0.1ml
EUR 432
Description: A polyclonal antibody for TNF alpha from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human TNFA.. The Antibody is tested and validated for IHC, ICC/IF, ELISA assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:500), ELISA (1:10000). This TNF alpha antibody is conjugated to ATTO 488.

Antibody for Human TNF alpha

SPC-1315D-A565 0.1ml
EUR 432
Description: A polyclonal antibody for TNF alpha from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human TNFA.. The Antibody is tested and validated for IHC, ICC/IF, ELISA assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:500), ELISA (1:10000). This TNF alpha antibody is conjugated to ATTO 565.

Antibody for Human TNF alpha

SPC-1315D-A594 0.1ml
EUR 432
Description: A polyclonal antibody for TNF alpha from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human TNFA.. The Antibody is tested and validated for IHC, ICC/IF, ELISA assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:500), ELISA (1:10000). This TNF alpha antibody is conjugated to ATTO 594.

Antibody for Human TNF alpha

SPC-1315D-A633 0.1ml
EUR 432
Description: A polyclonal antibody for TNF alpha from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human TNFA.. The Antibody is tested and validated for IHC, ICC/IF, ELISA assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:500), ELISA (1:10000). This TNF alpha antibody is conjugated to ATTO 633.

Antibody for Human TNF alpha

SPC-1315D-A655 0.1ml
EUR 432
Description: A polyclonal antibody for TNF alpha from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human TNFA.. The Antibody is tested and validated for IHC, ICC/IF, ELISA assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:500), ELISA (1:10000). This TNF alpha antibody is conjugated to ATTO 655.

Antibody for Human TNF alpha

SPC-1315D-A680 0.1ml
EUR 432
Description: A polyclonal antibody for TNF alpha from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human TNFA.. The Antibody is tested and validated for IHC, ICC/IF, ELISA assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:500), ELISA (1:10000). This TNF alpha antibody is conjugated to ATTO 680.

Antibody for Human TNF alpha

SPC-1315D-A700 0.1ml
EUR 432
Description: A polyclonal antibody for TNF alpha from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human TNFA.. The Antibody is tested and validated for IHC, ICC/IF, ELISA assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:500), ELISA (1:10000). This TNF alpha antibody is conjugated to ATTO 700.

Antibody for Human TNF alpha

SPC-1315D-ALP 0.1ml
EUR 426
Description: A polyclonal antibody for TNF alpha from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human TNFA.. The Antibody is tested and validated for IHC, ICC/IF, ELISA assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:500), ELISA (1:10000). This TNF alpha antibody is conjugated to Alkaline Phosphatase.

Antibody for Human TNF alpha

SPC-1315D-APC 0.1ml
EUR 430.8
Description: A polyclonal antibody for TNF alpha from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human TNFA.. The Antibody is tested and validated for IHC, ICC/IF, ELISA assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:500), ELISA (1:10000). This TNF alpha antibody is conjugated to APC .

Antibody for Human TNF alpha

SPC-1315D-APCCY7 0.1ml
EUR 518.4
Description: A polyclonal antibody for TNF alpha from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human TNFA.. The Antibody is tested and validated for IHC, ICC/IF, ELISA assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:500), ELISA (1:10000). This TNF alpha antibody is conjugated to APC/Cy7.

Antibody for Human TNF alpha

SPC-1315D-BI 0.1ml
EUR 428.4
Description: A polyclonal antibody for TNF alpha from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human TNFA.. The Antibody is tested and validated for IHC, ICC/IF, ELISA assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:500), ELISA (1:10000). This TNF alpha antibody is conjugated to Biotin.

Antibody for Human TNF alpha

SPC-1315D-DY350 0.1ml
EUR 523.2
Description: A polyclonal antibody for TNF alpha from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human TNFA.. The Antibody is tested and validated for IHC, ICC/IF, ELISA assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:500), ELISA (1:10000). This TNF alpha antibody is conjugated to Dylight 350.

Antibody for Human TNF alpha

SPC-1315D-DY405 0.1ml
EUR 494.4
Description: A polyclonal antibody for TNF alpha from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human TNFA.. The Antibody is tested and validated for IHC, ICC/IF, ELISA assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:500), ELISA (1:10000). This TNF alpha antibody is conjugated to Dylight 405.

Antibody for Human TNF alpha

SPC-1315D-DY488 0.1ml
EUR 471.6
Description: A polyclonal antibody for TNF alpha from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human TNFA.. The Antibody is tested and validated for IHC, ICC/IF, ELISA assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:500), ELISA (1:10000). This TNF alpha antibody is conjugated to Dylight 488.

Antibody for Human TNF alpha

SPC-1315D-DY594 0.1ml
EUR 476.4
Description: A polyclonal antibody for TNF alpha from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human TNFA.. The Antibody is tested and validated for IHC, ICC/IF, ELISA assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:500), ELISA (1:10000). This TNF alpha antibody is conjugated to Dylight 594.

Antibody for Human TNF alpha

SPC-1315D-DY633 0.1ml
EUR 464.4
Description: A polyclonal antibody for TNF alpha from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human TNFA.. The Antibody is tested and validated for IHC, ICC/IF, ELISA assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:500), ELISA (1:10000). This TNF alpha antibody is conjugated to Dylight 633.

Antibody for Human TNF alpha

SPC-1315D-FITC 0.1ml
EUR 423.6
Description: A polyclonal antibody for TNF alpha from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human TNFA.. The Antibody is tested and validated for IHC, ICC/IF, ELISA assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:500), ELISA (1:10000). This TNF alpha antibody is conjugated to FITC.

Antibody for Human TNF alpha

SPC-1315D-HRP 0.1ml
EUR 418.8
Description: A polyclonal antibody for TNF alpha from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human TNFA.. The Antibody is tested and validated for IHC, ICC/IF, ELISA assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:500), ELISA (1:10000). This TNF alpha antibody is conjugated to HRP.

Antibody for Human TNF alpha

SPC-1315D-P594 0.1ml
EUR 440.4
Description: A polyclonal antibody for TNF alpha from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human TNFA.. The Antibody is tested and validated for IHC, ICC/IF, ELISA assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:500), ELISA (1:10000). This TNF alpha antibody is conjugated to PE/ATTO 594.

Antibody for Human TNF alpha

SPC-1315D-PCP 0.1ml
EUR 430.8
Description: A polyclonal antibody for TNF alpha from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human TNFA.. The Antibody is tested and validated for IHC, ICC/IF, ELISA assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:500), ELISA (1:10000). This TNF alpha antibody is conjugated to PerCP.

Antibody for Human TNF alpha

SPC-1315D-RPE 0.1ml
EUR 429.6
Description: A polyclonal antibody for TNF alpha from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human TNFA.. The Antibody is tested and validated for IHC, ICC/IF, ELISA assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:500), ELISA (1:10000). This TNF alpha antibody is conjugated to RPE .

Antibody for Human TNF alpha

SPC-1315D-STR 0.1ml
EUR 430.8
Description: A polyclonal antibody for TNF alpha from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with Human Synthesized peptide derived from internal of human TNFA.. The Antibody is tested and validated for IHC, ICC/IF, ELISA assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:500), ELISA (1:10000). This TNF alpha antibody is conjugated to Streptavidin.

Rabbit Anti-Human alpha-Tubulin IgG

TUBA13-A 100 ul
EUR 578.4

Recombinant (E.Coli) Human p38 alpha/SAPK2 alpha

RP-675 1 ug
EUR 343.2

Monoclonal Anti-Human Tumor Necrosis Factor-Alpha (TNF-alpha) IgG #1 aff. Pure

TNFA11-M 100 ug
EUR 578.4

Monoclonal Anti-Human Tumor Necrosis Factor-Alpha (TNF-alpha) IgG #2, aff. Pure

TNFA12-M 100 ug
EUR 578.4

Monoclonal Anti-Human alpha-Tubulin IgG

TUBA12-M 100 ul
EUR 578.4

Rabbit Anti-Rat TNF-alpha Converting Enzyme (TACE) antiserum

TACE11-S 100 ul
EUR 548.4

Human TNF alpha Protein

abx060828-005mg 0.05 mg
EUR 661.2

Alpha 2-Antiplasmin, Human Plasma

A2AP15-100 100 ug
EUR 196.8

Alpha 1-Antitrypsin, Human Plasma

A1AT15-N 1 mg
EUR 196.8

Chicken Anti-Human alpha 1 anti-trypsin IgG/Y

A1AT12-A 100 ul
EUR 578.4

Rabbit Anti-Human p73 alpha antiserum # 2

P73A12-S 100 ul
EUR 548.4

Guinea pig Tumor Necrosis Factor Alpha (TNF-a) ELISA Kit, 96 tests, Quantitative

9870 1 Kit
EUR 927.6

Tumor necrosis factor alpha TNF-? (72 - 82), human (AA: Pro-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg) (MW: 1171.33)

SP-86635-5 5 mg
EUR 343.2

Rabbit Anti-Human Glutathione Transferase alpha (GST-alpha) antiserum

GSTA12-S 100 ul
EUR 548.4

Alpha 1-Antichymotrypsin , Human Plasma

A1CT15-N-100 100 ug
EUR 196.8

Goat Anti-Human Tumor Necrosis Factor-Alpha (TNF-alpha) IgG #2, aff. Pure (neutralzing)

TNFA13-A 100 ul
EUR 578.4

Rabbit Anti-Human Estrogen receptor alpha (ER-alpha) peptide IgG

ERA12-A 100 ug
EUR 578.4

Rabbit Anti-Human p73 alpha/beta antiserum # 1

P73A11-S 100 ul
EUR 548.4

Monoclonal anti-human Alpha (FSH-Alpha), IgG clone 3 aff pure

FSHA12-M 1 mg
EUR 578.4

Anti-mouse TNF alpha Antibody

RP1000 100ug/vial
EUR 400.8

Goat Anti-Human Lutenizing Hormone Alpha (LH-Alpha) IgG aff pure

LHA13-A 1 mg
EUR 343.2

human Topoisomerase II alpha (TOP2 alpha) Control/blocking peptide

TOP2A11-P 100 ug
EUR 196.8

Goat Anti-human Alpha fetoprotein (AFP) IgG, pure

AFP13-A 1 mg
EUR 781.2

Human TNF alpha ELISA kit

55R-IB49623 96 wells
EUR 1413.6
Description: ELISA kit for the detection of TNF alpha in the research laboratory

Human TNF alpha ELISA kit

55R-1690 1 kit
EUR 481.2
Description: ELISA kit for the detection of TNF alpha in the research laboratory

Goat Anti-human Chorionic Gonadotropin Alpha (hCG-Alpha) IgG aff pure

HCGA13-A 1 mg
EUR 343.2

Rabbit Anti-Human p73 alpha/ IgG # 2, aff pure

P73A12-A 100 ug
EUR 578.4

Rabbit Anti-Human HE2 alpha IgG #1, aff pure

HE2A11-A 100 ug
EUR 578.4

Human TNF Alpha (TNFA) Protein

20-abx670178
  • EUR 444.00
  • EUR 661.20
  • 10 ug
  • 50 ug

Recombinant (E.Coli) purified human Tumor Necrosis Factor-Alpha (TNF-alpha), biologically active

TNFA15-R-10 10 ug
EUR 270

Recombinant purified, human Interleukin-1 alpha (IL-1 alpha), active

IL1A15-R-10 10 ug
EUR 416.4

Rabbit Anti-Human alpha-Tubulin IgG-HRP Conjugate

TUBA13-HRP 100 ul
EUR 518.4

Recombinant Human Alpha-Synuclein

RP-847 20 ug
EUR 196.8

Tumor necrosis factor alpha TNF-? (78-96) (human) (AA: His-Thr-Ile-Ser-Arg-Ile-Ala-Val-Ser-Tyr-Gln-Thr-Lys-Val-Asn-Leu-Leu-Ser-Ala) (MW: 2101.45)

SP-89730-1 1 mg
EUR 196.8

Goat Anti-Ferret IgA (alpha), unlabeled

70519 0.5 mg
EUR 255.6

Rabbit Anti-Human alpha-Tubulin IgG-Biotin Conjugate

TUBA13-BTN 100 ul
EUR 562.8

Human Alpha-Thrombin (human plasma), purified

TBNA16-N-100 100 ug
EUR 196.8

Tumor necrosis factor alpha TNF-? (46-65) (human) (AA: Asn-Gln-Leu-Val-Val-Pro-Ser-Glu-Gly-Leu-Tyr-Leu-Ile-Tyr-Ser-Gln-Val-Leu-Phe-Lys) (MW: 2310.74)

SP-89728-1 1 mg
EUR 489.6

Rabbit Anti-Rat TNF-alpha Converting Enzyme (TACE), IgG aff. Pure

TACE11-A 100 ug
EUR 578.4

Rabbit Anti-Human Resistin-Like protein alpha (RELM-alpha/FIZZ1) antiserum #2

RELMA12-S 100 ul
EUR 548.4

Goat Anti-Human Alpha 1-Antitrypsin (A1AT) IgG, unlabeled

A1AT11-A 100 ul
EUR 489.6

Chicken Anti-Human Alpha 2 Macroglobulin (A2M) IgG/Y

A2MG13-A 100 ul
EUR 578.4

Rabbit Anti-Rat Glutathione Transferase alpha (GST-alpha) antiserum

GSTA11-S 100 ul
EUR 548.4

TNF alpha

GT15064 100 ug
EUR 631.2

TNF alpha

GT15113 100 ug
EUR 631.2

Rabbit Anti-Human p73 alpha/beta IgG # 1, aff pure

P73A11-A 100 ug
EUR 578.4

Tumor necrosis factor alpha TNF-? (31 - 45), human (AA: Arg-Arg-Ala-Asn-Ala-Leu-Leu-Ala-Asn-Gly-Val-Glu-Leu-Arg-Asp) (MW: 1667.90)

SP-86636-1 1 mg
EUR 196.8

anti-TNF alpha

YF-PA24865 50 ul
EUR 400.8
Description: Mouse polyclonal to TNF alpha

Monoclonal Anti-Human Chorionic Gonadotropin Alpha (hCG-alpha) IgG #1, aff pure

HCGA11-M 1 mg
EUR 343.2

TNF alpha antibody

10-T60A 1 mg
EUR 159.6
Description: Mouse monoclonal TNF alpha antibody

TNF alpha antibody

10-T60B 1 mg
EUR 536.4
Description: Mouse monoclonal TNF alpha antibody

TNF alpha antibody

10-T60C 1 mg
EUR 536.4
Description: Mouse monoclonal TNF alpha antibody

TNF alpha antibody

10-T60D 1 mg
EUR 522
Description: Mouse monoclonal TNF alpha antibody

TNF alpha antibody

10R-10252 50 ul
EUR 262.8
Description: Mouse monoclonal TNF alpha antibody

TNF alpha antibody

10R-2119 100 ul
EUR 457.2
Description: Mouse monoclonal TNF alpha antibody

TNF alpha antibody

10R-2976 100 ug
EUR 318
Description: Mouse monoclonal TNF alpha antibody

TNF alpha antibody

10R-2986 100 ug
EUR 318
Description: Mouse monoclonal TNF alpha antibody

TNF alpha antibody

10R-3098 100 ug
EUR 488.4
Description: Mouse monoclonal TNF alpha antibody

TNF alpha antibody

10R-3099 100 ug
EUR 488.4
Description: Mouse monoclonal HBxAg antibody

TNF alpha antibody

10R-6647 50 ug
EUR 184.8
Description: Mouse monoclonal TNF alpha antibody

TNF alpha antibody

10R-6648 50 ug
EUR 184.8
Description: Mouse monoclonal TNF alpha antibody

TNF alpha antibody

10R-6649 50 ug
EUR 184.8
Description: Armenian Hamster monoclonal TNF alpha antibody

TNF alpha antibody

10R-7734 500 ug
EUR 678
Description: Mouse monoclonal TNF alpha antibody

Elevated ranges of anti-dsDNA antibodies in immune complexes earlier than remedy with belimumab affiliate with scientific response in sufferers with systemic lupus erythematosus.

Immune complexes are of significance in systemic lupus erythematosus pathogenesis, and autoantibodies are believed to take part in immune advanced formation. Quantification of autoantibody ranges in circulating IC may be of prognostic worth.

 

  • A C1q-binding-eluting method was utilized to purify immune complexes from 55 belimumab-treated systemic lupus erythematosus sufferers throughout a 24-month follow-up. Autoantibodies in serum and in solubilized immune complexes have been quantified utilizing addressable laser bead immunoassay. We investigated whether or not ranges of autoantibodies in immune complexes affiliate with illness exercise and response to belimumab remedy.
  • Excessive baseline anti-double-stranded DNA and anti-histone ranges in immune complexes related to attainment of zero scores in scientific systemic lupus erythematosus illness exercise index 2000 through the 24-month follow-up (p = 0.003 and p = 0.048, respectively).
  • Low complement ranges related to excessive serum anti-double-stranded DNA and anti-ribosomal P ranges (p = 0.003 and p = 0.008, respectively) and excessive anti-double-stranded DNA (p = 0.002) however not anti-ribosomal P ranges in immune complexes. Anti-SSA/SSB serum ranges have been decrease in sufferers attaining lupus low illness exercise state at month 6; these associations have been stronger for corresponding immune advanced ranges.
  • Serum ranges of most autoantibodies had declined at month 3, whereas autoantibody ranges in immune complexes, apart from anti-double-stranded DNA, confirmed a extra gradual decline over 1-2 years. Serum anti-double-stranded DNA ranges decreased in all sufferers regardless of systemic lupus erythematosus illness exercise index 2000=Zero attainment, whereas immune advanced ranges decreased solely in achievers.
  • Immune advanced ranges of autoantibodies towards double-stranded DNA and the SSA/SSB advanced present extra particular associations with remedy consequence in contrast with serum ranges in belimumab-treated systemic lupus erythematosus sufferers. Characterization of autoantibody content material in circulating immune complexes might show helpful in remedy analysis in systemic lupus erythematosus and different immune complex-associated ailments.

No affiliation between anti-thyroidperoxidase antibodies and bipolar dysfunction: A examine within the Dutch Bipolar Cohort and a meta-analysis.

Thyroid autoimmunity has been related to bipolar dysfunction (BD). Nevertheless, outcomes from earlier research on the seroprevalence of anti-thyroid peroxidase antibodies (TPO-abs) in BD are inconsistent.

The purpose of the current examine is to research whether or not the seroprevalence and titer ranges of TPO-abs are associated to BD.TPO-abs have been measured in plasma samples of 760 sufferers with bipolar dysfunction, 261 first-degree family and 363 controls by enzyme-linked immunosorbent assay (ELISA).

To handle the methodological limitations of earlier research, we assessed scientific traits with a number of (self-reported) questionnaires to research whether or not TPO-abs positivity is said to specific scientific subgroups of BD sufferers. We carried out a further meta-analysis of seroprevalences of TPO-abs in BD sufferers together with information from current and former research.

Seroprevalence or titer ranges of TPO-abs didn’t considerably differ between sufferers with BD, their first-degree family, and controls. In BD sufferers, the prevalence of TPO-abs was unrelated to particular scientific elements, together with lithium use. Our meta-analysis of twelve research confirmed an total odds ratio of 1.3 (CI 95 %: 0.7-2.3; p = 0.30), reaffirming the absence of an affiliation of BD with TPO-abs. Within the largest examine of TPO-abs in BD so far, our findings point out that TPO-abs should not related to (the chance for) bipolar dysfunction.

 

IGF BP3 antibody

70R-IR022 50 ug
EUR 327.6
Description: Affinity purified Rabbit polyclonal IGF BP3 antibody

IGF BP5 antibody

70R-IR023 50 ug
EUR 327.6
Description: Affinity purified Rabbit polyclonal IGF BP5 antibody

IGF BP7 antibody

70R-IR024 50 ug
EUR 327.6
Description: Affinity purified Rabbit polyclonal IGF BP7 antibody

IGF BP2 protein

30R-AI105 20 ug
EUR 327.6
Description: Purified recombinant Human IGF BP2 protein

IGF BP6 protein

30R-AI106 25 ug
EUR 327.6
Description: Purified recombinant Human IGF BP6 protein

IGF BP7 protein

30R-AI120 25 ug
EUR 327.6
Description: Purified recombinant Human IGF BP7 protein

IGF BP1 protein

30R-AI121 25 ug
EUR 327.6
Description: Purified recombinant Human IGF BP1 protein

IGF BP3 protein

30R-AI122 25 ug
EUR 327.6
Description: Purified recombinant Human IGF BP3 protein

IGF BP5 protein

30R-AI124 25 ug
EUR 327.6
Description: Purified recombinant Human IGF BP5 protein

IGF-BP3, Human

HY-P7020 10ug
EUR 280.8

IGF-BP5, Human

HY-P7021 50ug
EUR 721.2

IGF-BP3, human

RC216-12B3 5ug
EUR 125.26

IGF-1, Human

HY-P7018 10ug
EUR 129.6

IGF-2, Human

HY-P7019 100ug
EUR 432

IGF-1, human

RC216-12 1mg
EUR 451.5

Antibody for Human IGF-1

SPC-699D-ALP 0.1mg
EUR 472.8
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to Alkaline Phosphatase.

Antibody for Human IGF-1

SPC-699D-DY350 0.1mg
EUR 496.8
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to Dylight 350.

Antibody for Human IGF-1

SPC-699D-DY405 0.1mg
EUR 483.6
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to Dylight 405.

Antibody for Human IGF-1

SPC-699D-DY488 0.1mg
EUR 471.6
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to Dylight 488.

Antibody for Human IGF-1

SPC-699D 0.1mg
EUR 424.8
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is unconjugated.

Antibody for Human IGF-1

SPC-699D-A390 0.1mg
EUR 481.2
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to ATTO 390.

Antibody for Human IGF-1

SPC-699D-A488 0.1mg
EUR 480
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to ATTO 488.

Antibody for Human IGF-1

SPC-699D-A565 0.1mg
EUR 480
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to ATTO 565.

Antibody for Human IGF-1

SPC-699D-A594 0.1mg
EUR 480
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to ATTO 594.

Antibody for Human IGF-1

SPC-699D-A633 0.1mg
EUR 480
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to ATTO 633.

Antibody for Human IGF-1

SPC-699D-A655 0.1mg
EUR 480
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to ATTO 655.

Antibody for Human IGF-1

SPC-699D-A680 0.1mg
EUR 480
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to ATTO 680.

Antibody for Human IGF-1

SPC-699D-A700 0.1mg
EUR 480
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to ATTO 700.

Antibody for Human IGF-1

SPC-699D-APC 0.1mg
EUR 478.8
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to APC .

Antibody for Human IGF-1

SPC-699D-APCCY7 0.1mg
EUR 565.2
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to APC/Cy7.

Antibody for Human IGF-1

SPC-699D-BI 0.1mg
EUR 475.2
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to Biotin.

Antibody for Human IGF-1

SPC-699D-DY594 0.1mg
EUR 474
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to Dylight 594.

Antibody for Human IGF-1

SPC-699D-DY633 0.1mg
EUR 468
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to Dylight 633.

Antibody for Human IGF-1

SPC-699D-FITC 0.1mg
EUR 470.4
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to FITC.

Antibody for Human IGF-1

SPC-699D-HRP 0.1mg
EUR 465.6
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to HRP.

Antibody for Human IGF-1

SPC-699D-P594 0.1mg
EUR 488.4
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to PE/ATTO 594.

Antibody for Human IGF-1

SPC-699D-PCP 0.1mg
EUR 478.8
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to PerCP.

Antibody for Human IGF-1

SPC-699D-RPE 0.1mg
EUR 476.4
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to RPE .

Antibody for Human IGF-1

SPC-699D-STR 0.1mg
EUR 477.6
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to Streptavidin.

Antibody for Human IGF-1

SPC-699S 0.012mg
EUR 78
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is unconjugated.

Human Salivary IGF(salivary IGF) ELISA Kit

QY-E05383 96T
EUR 433.2

Human IGF-1 LR3

SP-89927-100 100 ug
EUR 270

Anti-Rat IGF-1 Antibody

5121-100 each
EUR 379.2

Anti-Rat IGF-1 Antibody

5121-30T each
EUR 175.2

IGF-BP2, human recombinant

7165-10 each
EUR 301.2

IGF-BP2, human recombinant

7165-50 each
EUR 1123.2

IGF-BP7, human recombinant

7167-10 each
EUR 248.4

IGF-BP7, human recombinant

7167-50 each
EUR 810

IGF-BP6, human recombinant

7350-20 each
EUR 444

IGF-BP1, human recombinant

4717-100 each
EUR 744

IGF-BP1, human recombinant

4717-1000 each
EUR 3778.8

IGF-BP1, human recombinant

4717-25 each
EUR 307.2

IGF-BP3, human recombinant

4720-100 each
EUR 744

IGF-BP3, human recombinant

4720-1000 each
EUR 3778.8

IGF-BP3, human recombinant

4720-25 each
EUR 307.2

IGF-BP5, human recombinant

4723-100 each
EUR 744

IGF-BP5, human recombinant

4723-1000 each
EUR 3778.8

IGF-BP5, human recombinant

4723-25 each
EUR 307.2

Recombinant Human IGF-1

HEGFP-0901 100ug Ask for price

Recombinant Human IGF-2

HEGFP-0908 10ug Ask for price

Human IGF-I monoclonal antibody

MAM1 500 µg
EUR 358.8

IGF-1, human recombinant

P1016-.02 20 µg
EUR 309.6
Description: Insulin-like growth factor I (IGF-1) is a polypeptide endocrine hormone structurally similar to insulin and is mainly produced in the liver when stimulated by growth hormone. IGF-1 is a growth factor that stimulates the proliferation of various cell types including muscle, bone, and cartilage tissue

IGF-1, human recombinant

P1016-.1 100 µg
EUR 915.6
Description: Insulin-like growth factor I (IGF-1) is a polypeptide endocrine hormone structurally similar to insulin and is mainly produced in the liver when stimulated by growth hormone. IGF-1 is a growth factor that stimulates the proliferation of various cell types including muscle, bone, and cartilage tissue

rec IGF-I (human)

H-5555.0050 50.0µg
EUR 290.4
Description: CAS# [67763-96-6]

rec IGF-I (human)

H-5555.0100 100.0µg
EUR 457.2
Description: CAS# [67763-96-6]

rec IGF-I (human)

H-5555.0500 0.5mg
EUR 1720.8
Description: CAS# [67763-96-6]

Human IGF-I Protein

abx060791-100ug 100 ug
EUR 560.4

Biotinyl Human IGF-I

AQU010 10 µg
EUR 303.6

Biotinyl Human IGF-I

AQU050 50 µg
EUR 415.2

Biotinyl Human IGF-I

AQU100 100 µg
EUR 637.2

Biotinyl Human IGF-I

AQU500 500 µg
EUR 1305.6

Recombinant Human IGF-2/ IGF-II Protein, GST, E.coli-1mg

QP8601-ec-1mg 1mg
EUR 1958.4

Recombinant Human IGF-2/ IGF-II Protein, GST, E.coli-10ug

QP8601-ec-10ug 10ug
EUR 240

Recombinant Human IGF-2/ IGF-II Protein, GST, E.coli-50ug

QP8601-ec-50ug 50ug
EUR 315.6

Human [Ala31] IGF-I

AIU020 20 µg
EUR 303.6

Human [Ala31] IGF-I

AIU100 100 µg
EUR 415.2

Human [Leu60] IGF-I

ABU020 20 µg
EUR 303.6

Human [Leu60] IGF-I

ABU100 100 µg
EUR 415.2

Human [Arg6] IGF-II

GU020 20 µg
EUR 303.6

Human [Leu24] IGF-I

ZU020 20 µg
EUR 303.6

Human [Leu24] IGF-I

ZU100 100 µg
EUR 415.2

Recombinant Human IGF-2/ IGF-II Protein, GST, E.coli-100ug

QP8601-ec-100ug 100ug
EUR 489.6

Recombinant Human IGF-2/ IGF-II Protein, GST, E.coli-200ug

QP8601-ec-200ug 200ug
EUR 760.8

Recombinant Human IGF-2/ IGF-II Protein, GST, E.coli-500ug

QP8601-ec-500ug 500ug
EUR 1272

Human [Leu27]IGF-II

TU100 100 µg
EUR 415.2

Human IGF-2 ELISA Kit

EHI0307 96Tests
EUR 625.2

Human IGF-1 ELISA Kit

RK00160 96 Tests
EUR 625.2

Recombinant Human IGF-2/ IGF-II Protein, Untagged, E.coli-1mg

QP5264-1mg 1mg
EUR 1513.2

Recombinant Human IGF-2/ IGF-II Protein, Untagged, E.coli-10ug

QP5264-10ug 10ug
EUR 163.2

Recombinant Human IGF-2/ IGF-II Protein, Untagged, E.coli-50ug

QP5264-50ug 50ug
EUR 284.4

Recombinant Human IGF-2/ IGF-II Protein, Untagged, E.coli-100ug

QP5264-100ug 100ug
EUR 435.6

Recombinant Human IGF-2/ IGF-II Protein, Untagged, E.coli-500ug

QP5264-500ug 500ug
EUR 914.4

Recombinant Human IGF-BP1 Protein

PROTP08833-1 25ug
EUR 380.4
Description: IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP1 is a 25.4 kDa cysteine-rich secreted protein expressed in liver, deciduas, and kidneys and is the most abundant IGF-BP in amniotic fluid. Levels of IGF-BP1 in serum are lowest after food. IGF-BP1 binds to both IGF-I and IGF-II with equal affinity. Phosphorylated IGF-BP1 hinders IGF actions, where as nonphosphorylated IGF-BP1 is stimulatory. Recombinant human IGF-BP1 is a 25.4 kDa protein consisting of 235 amino acid residues (Isoform A).

Recombinant Human IGF-BP3 Protein

PROTP17936-2 25ug
EUR 380.4
Description: IGF-BP3 is a 30 kDa cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals and it is also found in α-granules of platelets. In addition to its ability to modulate the activity of IGF-I and IGF-II, IGF-BP3 exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF, and EGF. Recombinant human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues.

Recombinant Human IGF-BP2 Protein

PROTP18065 20ug
EUR 380.4
Description: IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP2 is a cysteine-rich secreted protein produced by bone cells, and is most abundant in the brain. IGF-BP2 has been shown to inhibit IGF-II action in human breast and ovarian carcinoma cells. Recombinant human IGF-BP2 is a 31.5 kDa protein consisting of 289 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.

*Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.

Recombinant Human IGF-BP6 Protein

PROTP24592-2 20ug
EUR 380.4
Description: IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. IGF-BP6 is produced by bone cells and is the major IGF-BP present in cerebrospinal fluid, and specifically inhibits IGF-II actions. IGF-BP6 has been shown to inhibit IGF-II-dependent cancers such as neuroblastoma, colon cancer and rhabdomyosarcoma. Recombinant human IGF-BP6 has a calculated mass of 22.6 kDa and consists of 213 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain. IGF-BP6 migrates at an apparent molecular weight of approximately 23.0-30.0 kDa by SDS-PAGE analysis under non-reducing conditions.

*Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.

Recombinant Human IGF-BP5 Protein

PROTP24593-1 25ug
EUR 380.4
Description: IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP5 is a 28.6 kDa cysteine-rich secreted protein produced by vascular smooth muscle cells. It is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGF-I on smooth muscle cells, fibroblasts or osteoblasts. Data shows that IGFBP-5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGFBP-5 overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole-body growth inhibition and retarded muscle development. Recombinant human IGF-BP5 is a 28.6 kDa protein consisting of 253 amino acid residues.

Recombinant Human IGF-BP7 Protein

PROTQ16270-2 25ug
EUR 380.4
Description: IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP7 is expressed in a wide range of normal human tissues and it generally shows reduced expression in cancer cell lines of prostate, breast, colon, and lung origin. It plays a role in skeletal myogenesis by binding to IGF in a manner that inhibits IGF induced differentiation of skeletal myoblasts, without affecting IGF induced proliferation. Additionally, IGF-BP7 suppresses growth and colony formation of prostate and breast cancer cell lines through an IGF independent mechanism, which causes a delay in the G1 phase of the cell cycle, and increased apoptosis. Recombinant human IGF-BP7 is a 26.4 kDa protein consisting of 256 amino acid residues.

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